Publication list (2010〜2011)

University of Tokyo (Miyazono)

  1. Shirai YT, Ehata S, Yashiro M, Yanagihara K, Hirakawa K, Miyazono K. Bone Morphogenetic Proteins 2 and 4 Play Tumor Suppressive Roles in Human Diffuse-Type Gastric Carcinoma. Am J Pathol. 2011; Oct 10. [Epub ahead of print] PubMed PMID: 21996676.
  2. Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K. Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4. J Biol Chem. 2011; Oct 10. [Epub ahead of print] PubMed PMID:21987575.
  3. Mihira H, Suzuki HI, Akatsu Y, Yoshimatsu Y, Igarashi T, Miyazono K, Watabe T.TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. J Biochem. 2011; Oct 8. [Epub ahead of print] PubMed PMID: 21984612.
  4. Miyazono K. Ectodomain shedding of HB-EGF: A potential target for cancer therapy. J Biochem. 2011; Oct 5. [Epub ahead of print] PubMed PMID: 21976708.
  5. Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J Cell Sci. 2011; 124(Pt 16): 2753-2762.
  6. Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K. RB1CC1 protein positively regulates transforming growth factor-β signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem. 2011; 286(37): 32502-32512.
  7. Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 2011; Jul 15. [Epub ahead of print] PubMed PMID: 21764776.
  8. Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H. Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A. 2011; 108(30): 12384-12389.
  9. Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem. 2011; 286(34): 29848-29860.
  10. Ikushima H, Miyazono K. Biology of Transforming Growth Factor-β Signalin. Curr Pharm Biotechnol. 2011; May 27. [Epub ahead of print] PubMed PMID: 21619537.
  11. Ikushima H, Miyazono K. TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β. Cell Tissue Res. 2011; May 27. [Epub ahead of print] PubMed PMID: 21618142.
  12. Miyazono K. Molecular mechanisms of transforming growth factor-β signaling and disease: The 59th Fujihara International Seminar, 2010. Cancer Sci. 2011; 102(6): 1242-1244.
  13. Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S. Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A. 2011; 108(12): 4938-4943.
  14. Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M. TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 2011; 30(4): 783-795.
  15. Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K. Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. Oncogene. 2011; 30(14): 1693-1705.
  16. Miyazono K, Koinuma D. Arkadia--beyond the TGF-β pathway. J Biochem. 2011; 149(1): 1-3.
  17. Suzuki HI, Miyazono K. Emerging complexity of microRNA generation cascades. J Biochem. 2011; 149(1): 15-25.
  18. Hoshino Y, Katsuno Y, Ehata S, Miyazono K. Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. J Biochem. 2011; 149(1): 55-65.
  19. Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem. 2010; 148(6): 733-41.
  20. Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K. Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 2010; 101(11): 2398-403.
  21. Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S. LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood. 2010; 116(23): 5060-70.
  22. Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-β family type I receptors through two distinct modes of interaction. J Biol Chem. 2010; 285(40): 30804-13.
  23. Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K. Identification of a phosphorylation site in c-Ski as serine 515. J Biochem. 2010; 148(4): 423-7.
  24. Suzuki HI, Miyazono K. Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway. J Mol Med. 2010; 88(11): 1085-94.

University of Tokyo (Ijichi)

  1. Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest. 2011; 121(10): 4106-4117.
  2. Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K. Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. J Hepatol. 2011; May 19. [Epub ahead of print] PubMed PMID: 21703185.
  3. Ijichi H. Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations. World J Clin Oncol. 2011; 2(5):195-202.
  4. Tada M, Nakai Y, Sasaki T, Hamada T, Nagano R, Mohri D, Miyabayashi K,Yamamoto K, Kogure H, Kawakubo K, Ito Y, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Omata M, Koike K. Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers. World J Clin Oncol. 2011;2(3): 158-163.
  5. Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Yamamoto K, Kogure H, Sasaki T, Hirano K, Ijichi H, Tateishi K, Yoshida H, Koike K. Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas. Gut. 2011; (9):1249-1253.
  6. Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M. Reduced expression of RAS protein activator like-1 in gastric cancer. Int J Cancer. 2011; 128(6):1293-1302.
  7. Nakai Y, Isayama H, Ijichi H, Sasaki T, Sasahira N, Hirano K, Kogure H, Kawakubo K, Yagioka H, Yashima Y, Mizuno S, Yamamoto K, Arizumi T, Togawa O, Matsubara S, Tsujino T, Tateishi K, Tada M, Omata M, Koike K. Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br J Cancer. 2010; 103(11):1644-1648.
  8. Nakai Y, Isayama H, Sasaki T, Sasahira N, Ito Y, Kogure H, Togawa O, Matsubara S, Arizumi T, Yagioka H, Yashima Y, Kawakubo K, Mizuno S, Yamamoto K, Hirano K, Tsujino T, Ijichi H, Tateishi K, Toda N, Tada M, Omata M, Koike K. Impact of S-1 on the survival of patients with advanced pancreatic cancer. Pancreas. 2010; 39(7): 989-993.
  9. Nakai Y, Isayama H, Sasaki T, Sasahira N, Kogure H, Hirano K, Tsujino T, Ijichi H, Tateishi K, Tada M, Omata M, Koike K. Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan. Jpn J Clin Oncol. 2010; 40(8): 774-780.
  10. Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K. Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion. Biochem Biophys Res Commun. 2010; 394(4): 1042-1046.
  11. Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M. Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. J Biol Chem. 2010; 285(6): 4185-4194.
  12. Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Otsuka M, Ijichi H, Ikenoue T, Tateishi K, Akanuma M, Ogura K, Yoshida H, Ichijo H, Omata M, Maeda S. Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses. Gastroenterology. 2010; 138(3):1055-1067

Tsukuba University (Kato)

  1. Yang W, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, Itoh S, Kato M. Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2. Cancer Sci. 2011 Jul 1. [Epub ahead of print]
  2. Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, Kato M, Hasegawa H, Kanaho Y. Tissue- and development-dependent expression of the small GTPase Arf6 in mice. Dev Dyn. 2010; 239(12): 3416-3435.
  3. Nakano N, Itoh S, Watanabe Y, Maeyama K, Itoh F, Kato M. Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene. J Biol Chem. 2010; 285(49): 38023-38033.
  4. Taguchi S, Kawachi Y, Ishitsuka Y, Fujisawa Y, Furuta J, Nakamura Y, Xu X, Ikebe D, Kato M, Otsuka F. Overexpression of the transcription factor Yin-Yang-1 suppresses differentiation of HaCaT cells in three-dimensional cell culture. J Invest Dermatol. 2011; 131(1): 37-45.
  5. Ohshima M, Yamaguchi Y, Matsumoto N, Micke P, Takenouchi Y, Nishida T, Kato M, Komiyama K, Abiko Y, Ito K, Otsuka K and Kappert K. TGF-b Signaling in Gingival Fibroblast-Epithelial Interaction. J Dent Res. 2010; 89: 1315-1321. 　
  6. Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood. 2010; 115(20): 4138-4147.
  7. Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M. TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins from active participation in TGF-β signaling. Mol Cell. 2010; 37(1): 123-134.
  8. Sonkoly E, Wei T, Pavez Loriè E, Suzuki H, Kato M, Törmä H, Ståhle M, Pivarcsi A. Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes. J Invest Dermatol. 2010; 130(1): 124-134.
  9. Kashiwagi Y, Horie K, Kanno C, Inomata M, Imamura T, Kato M, Yamamoto T,Yamashita H. Trichostatin A-induced TGF-β type II receptor expression in retinoblastoma cell lines. Invest Ophthalmol Vis Sci. 2010; 51(2): 679-685.

University of Yamanashi (Miyazawa)

  1. Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K. Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4. J Biol Chem. 2011; Oct 10. [Epub ahead of print]
  2. Horiguchi, K., Sakamoto, K., Koinuma, D., Semba, K., Inoue, A., Inoue, S., Fujii, H., Yamaguchi, A., Miyazawa, K., Miyazono K., and Saitoh, M. (2011) TGF-b drives epithelial-mesenchymal transition through dEF1-mediated downregulation of ESRP. Oncogene in press
  3. Kawasaki K., and Miyazawa, K. (2011) Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells. in Embryonic Stem Cells – Differentiation and Pluripotent Alternatives (ISBN 978-953-307-632-4). (Ed. Michael S. Kallos) pp245-266. In Tech, Rijeka (Croatia).
  4. Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K. RB1CC1 protein positively regulates transforming growth factor-β signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem. 2011; 286(37): 32502-32512.
  5. Miyazawa K. Encountering unpredicted off-target effects of pharmacological inhibitors. J Biochem. 2011; 150(1):1-3.
  6. Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M. TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 2011; 30(4): 783-795.
  7. Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. J Biol Chem. 2011; 286(8): 6311-6320.
  8. Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem. 2010; 148(6): 733-741.
  9. Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-β family type i receptors through two distinct modes of interaction. J Biol Chem. 2010; 285(40): 30804-30813.
  10. Nagata M, Nagata S, Yuki K, Isogaya K, Saitoh M, Miyazono K, Miyazawa K. Identification of a phosphorylation site in c-Ski as serine 515. J Biochem. 2010; 148(4): 423-427.
  11. Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010; 277(10): 2208-2214.
  12. Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem. 2010; 147(4): 545-554.

Toyama University (Beppu)

  1. Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V. BMPR-II is dispensable for formation of the limb skeleton. Genesis. 2011; 49(9): 719-724.
  2. Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011; 31(1): 346-358.
  3. Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I. Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice. Hippocampus. 2011; 21(6): 678-687.
  4. Beppu H. Transgenic and knockout mouse models for pulmonary hypertension: role of BMPR2 Part I; Genetically manipulated mouse models of pulmonary vascular disease and lung injury. Drug Discovery Toay: Disease Models. 2011; 71(3-4): 61-65.

Showa Pharmaceutical University (Itoh)

  1. Itoh S, Itoh F. Inhibitory machinery for the TGF-β family signaling pathway. Growth Factors. 2011; 29(5): 163-173.
  2. Yang W, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, Itoh S, Kato M. Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2. Cancer Sci. 2011; Jul 1. [Epub ahead of print] PubMed PMID: 21722264.
  3. Ishitobi H, Matsumoto K, Azami T, Itoh F, Itoh S, Takahashi S, Ema M. Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. Exp Anim. 2010; 59(5):615-622.
  4. Nakano N, Itoh S, Watanabe Y, Maeyama K, Itoh F, Kato M. Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene. J Biol Chem. 2010; 285(49):38023-38033.
  5. Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood. 2010; 115(20): 4138-4147.
  6. Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M. TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins from active participation in TGF-β signaling. Mol Cell. 2010; 37(1):123-134.

Ehime University (Imamura)

  1. Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K. RB1CC1 protein positively regulates transforming growth factor-β signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem. 2011; 286(37): 32502-32512.
  2. Imamura T, Hikita A, Sasaki M, Honkura N. [Bone analysis by in vivo optical imaging]. Clin Calcium. 2011; 21(7): 1036-1040.
  3. Imamura T, Hanyu A, Hikita A. [In vivo optical imaging of cancer]. Seikagaku. 2011; 83(5): 406-409.
  4. Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T, Matsuoka M. HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood. 2011; 118(7): 1865-1876.
  5. Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem. 2011;286(34): 29848-29860.
  6. Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, Hirose J, Omata Y, Yasuda H, Imamura T, Nakamura K, Tanaka S. Regulation of RANKL-inducedosteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6. J Bone Miner Res. 2011; 26(7): 1447-1456.
  7. Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. J Biol Chem. 2011; 286(8): 6311-6320.
  8. Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T. Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts. PLoS One. 2010; 5(9): pii: e13090.
  9. Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J. Estrogen inhibits transforming growth factor b signaling by promoting Smad2/3 degradation. J Biol Chem. 2010; 285(19): 14747-14755.
  10. Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S. Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010; 137(7): 1159-1167.
  11. Kashiwagi Y, Horie K, Kanno C, Inomata M, Imamura T, Kato M, Yamamoto T, Yamashita H. TGF-b type II Receptor mRNA in Retinoblastoma Cell Lines is induced by Trichostatin A. Invest Ophthalmol Vis Sci. 2010; 51(2): 679-685.

 

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